전임교수

옥민호

직위(직급): 교수

연구분야: 약물학

전화번호: 061-450-2681

이메일: mhoak@mnu.ac.kr

사무실: 약학관(C39) 4203호

교수소개

옥민호

직위(직급): 교수

이메일: mhoak@mnu.ac.kr

연구분야: 약물학

전화번호: 061-450-2681

사무실: 약학관(C39) 4203호

■ 학력사항

루이스-파스퇴르 대학 : 약학과(약학박사)

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이은영

직위(직급): 교수

연구분야: 독성학

전화번호: 061-450-2683

이메일: eunyoungyi@mnu.ac.kr

사무실: 약학관(C39) 4107호

교수소개

이은영

직위(직급): 교수

이메일: eunyoungyi@mnu.ac.kr

연구분야: 독성학

전화번호: 061-450-2683

사무실: 약학관(C39) 4107호

■ 학력사항

전남대학교 : 제약학과(약학사)

전남대학교 : 약학과(약학석사)

University of Mississippi Medical Center : Pharmacology & Toxicology (Ph.D)

■ 논문실적

2004 : Catecholamines and 5-hydroxytryptamine in tissues of the rabbit exocrine pancreas. Pancreas, 29(3), 218-224, 2004

2004 : Noradrenergic innervation of rabbit pancreatic ganglia. Autonom Neurosci.,117(2), 87-96, 2005

2005 : Alpha-adrenergic modulation of synaptic transmission in rabbit pancreatic ganglia. Autonom Neurosci.,122(1-2), 45-57, 2005

2005 : Short-term synaptic plasticity in rabbit pancreatic ganglia. Synaptic plasticity in rabbit pancreatic ganglia. Autonom Neurosci., 119(1), 36-47, 2005

2006 : Progressive deafness and altered cochlear innervation in knock-out mice lacking prosaposin. J Neurosci. 26(50),13076-13088, 2006

2006 : The glutamate-aspartate transporter GLAST mediates glutamate uptake at inner hair cell afferent

synapses in the mammalian cochlea. J Neurosci.26(29), 7659-7664, 2006

2007 : Autonomic pathways regulating pancreatic exocrinesecretion. Autonom Neurosci. 133(1), 19-34, 2007

2007 : The origin of spontaneous activity in the developing auditory system. Nature 450(7166), 50-5, 2007

2008 : Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3. Neuron 57(2),263-75, 2008

2008 : Differentiation of inner ear stem cells to functional sensory neurons. Dev Neurobiol.68(5), 669-84,2008

2010 : Dendritic HCN Channels Shape Excitatory Postsynaptic Potentials at the Inner Hair Cell Afferent

Synapse in the Mammalian Cochlea. J Neurophysiol. 103(5), 2532-2543, 2010

2010 : Two Modes of Release Shape the Postsynaptic Response at the Inner Hair Cell Ribbon Synapse. J Neurosci. 30(12), 4210-20,2010

2011 : Postsynaptic recordings at afferent dendrites contacting cochlear inner hair cells: monitoring

multivesicular release at a ribbon synapse. J Vis Exp,48, 2011

2013: Developmental Role of Anoctamin-1/TMEM16A in Ca2+-DependentVolume Change in Supporting Cells of the Mouse Cochlea. Exp Neurobiol. 22(4), 322-9, 2013

2014: Voltage-gated K+ channels contributing totemporal precision at the inner hair cell-auditory afferent nerve fibersynapses in the mammalian cochlea. Arch Pharm Res. 37(7), 821-33, 2014

2017 : Rice Bran Extract Inhibits TMEM16A-Involved Activityin the Neonatal Rat Cochlea. J Nanosci Nanotechnol. 17(4), 2390-2393, 2017

2017 : ATP1A3 mutations can cause progressive auditory neuropathy: a new gene of auditory synaptopathy. Scientific Reports. 7, 16504. doi:10.1038/s41598-017-16676-9, 2017

2018 : Differential e-x-p-r-e-s-s-i-o-n of Ca2+-bufferingProtein Calretinin in Cochlear Afferent Fibers: A Possible Link to Vulnerability to Traumatic Noise. Exp Neurobiol. 27(5), 397-407, 2018

2018 : Combination of Garcinia cambogia extract and pear pomace extract additively suppresses adipogenesis and enhances lipolysis in 3T3-L1 cells. Pharmacog Mag. 14(54), 220-226, 2018

2019 : Citrus junos Fruit Extract Facilitates Anti-Adipogenic Activity of Garcinia cambogia Extract in 3T3-L1 Adipocytes by Reducing Oxidative Stress. J Nanosci Nanotechnol. 19(2), 915-921, 2019

2019 : Fine air pollution particles induce endothelial senescence via redox-sensitive activation of local angiotensin system. Environ Pollut. 252(Pt A), 317-329. doi: 10.1016/j.envpol.2019.05.066. PMID:31158660, 2019

2020 : Distribution of Kv3 Subunits in Cochlear Afferent and Efferent Nerve Fibers Implies Distinct Role in Auditory Processing. Exp Neurobiol. 29(5), 344-355. doi: 10.5607/en20043. PMID: 33154197, 2020

2020 : Selective Loss of Calretinin-Poor Cochlear AfferentNerve Fibers in Streptozotocin-Induced Hyperglycemic Mice. J Nanosci Nanotechnol. 20(9), 5515-5519. doi: 10.1166/jnn.2020.17654. PMID: 32331128,2020

2020 : Sound exposure dynamically induces dopamine synthesis in cholinergic LOC efferents for feedback to auditory nerve fibers. Elife.9, e52419. doi: 10.7554/eLife.52419, 2020

2021 : A Deafness Associated Protein TMEM43 Interacts with KCNK3 (TASK-1) Two-pore Domain K+

(K2P) Channel in the Cochlea. Exp Neurobiol. 30(5),319-328. doi: 10.5607/en21028. PMID: 34737237, 2021

2021 : A nonsense TMEM43 variant leads to disruption of connexin-linked function and autosomal

dominant disorder. Proc Natl Acad Sci U S A.118(22), e2019681118. doi: 10.1073/pnas.2019681118. PMID: 34050020, 2021

2022 : Low-voltage Activating K+ Channels in Cochlear Afferent Nerve Fiber Dendrites. Exp Neurobiol. 31(4), 243-259. doi:10.5607/en22013. PMID: 36050224, 2022

■ 저서실적

2017 : 예방약학 9판 (신일북스)

2017 : 병태생리학 9판 (범문에듀케이션)

2019 : 병태생리학요약집 (범문에듀케이션)

■ 학술활동

2011 : e-x-p-r-e-s-s-i-o-n of calcium-activated chloride channel TMEM16A in developing mouse cochlea. 2011 Fall International convention of the Pharmaceutical Society of Korea

2012 : Developmental changes in e-x-p-r-e-s-s-i-o-n of calcium-activated chloride channel TMEM16A in mouse organ of Corti. 2012 Spring International convention of the Pharmaceutical Society of Korea

2012 : e-x-p-r-e-s-s-i-o-n of calcium-activated chloride channel TMEM16A in developing cochlea. 2012 International ion channel conference

2012 : Spontaneous volume change mediated by calcium-activated chloride channel, tmem16a, in developing mouse cochlea supporting cells. Society for Neuroscience 2012

2013 : Cannabinoid Signaling in the Mammalian Inner Ear. Cannabinoid function in the CNS-Gordon Research Conferences/Gordon Research Seminar

2013 : e-x-p-r-e-s-s-i-o-n of voltage-gated potassium channel Kv1.1 in Inner Hair Cell Afferent Synapses of Mammalian Cochlea. 2013 Fall International convention of the Pharmaceutical Society of Korea

2013 : Localization of Voltage-gated potassium channel Kv3.1b in Inner Hair Cell Afferent Synapses of Mammalian Cochlea. 2013 Fall International convention of the Pharmaceutical Society of Korea

2014 : MONNA, a TMEM16A Antagonist, Blocks Spontaneous Activities in Inner Supporting Cells ofthe Developing Rat Cochlea. 2014 Fall International convention of the Pharmaceutical Society of Korea

2014 : High- and low-voltage activating K+ channels expressed at the dendritic terminals of auditory afferent nerve fibers in the mammalian cochlea. 2014 Fall International convention of the Pharmaceutical Society of Korea

2015 : TMEM16A, a calcium activated chloride channel, modulates spontaneous activity in developing mammalian cochlea. 2015 Fall International convention of the Pharmaceutical Society of Korea

2016 : Anti-adipogenic effect of the mixture of Garcinia cambogia and Pyrus pyrifolia extracts in 3T3-L1 adipocytes. 2016 Spring International convention of the Pharmaceutical Society of Korea

2016 : Voltage-gated ion channels in cochlear afferent nerve fiber as potential target of lateral efferent modulation. 2016 한국청각언어재활학회 audiology seminar

2017 : Spontaneous activity and volume regulation of neonatal cochlear supporting cells. 2017 Auditory Research Symposium

2017 : Citrus junos fruit extract suppresses lipid accumulation and ROS production in 3T3-L1 adipocytes by reducing oxidative stress. 2017 Fall International convention of the Pharmaceutical Society of Korea

2018 : The e-x-p-r-e-s-s-i-o-n of neuroprotective Ca2+ buffering protein calretinin in aged cochlear spiral ganglion. 2018 Fall International convention of the Pharmaceutical Society of Korea

2018 : Anti-adipogenic flavonoid glycosides in the fruit juice from Citrus junos. 2018 Fall International convention of the Pharmaceutical Society of Korea

2019 : The role of D1-line and D2-like Dopamine receptors in lateral olivocochlear efferent function. 42nd Annual ARO Midwinter Meeting

2019 : Differential e-x-p-r-e-s-s-i-o-n of calcium-buffering protein calretinin in cochlear afferent fibers. 42nd Annual ARO Midwinter Meeting

2019 : The role of D1-like and D2-like dopamine receptors in lateral olivocochlear efferent function. IEB2019

2019 : Calretinin-poor cochlear afferent fibers are preferntially lost in aged mouse cochlea. IBRO2019

2019 : e-x-p-r-e-s-s-i-o-n of Kv3.4 potassium channel in the rat cochlea. 2019 Fall International convention of the Pharmaceutical Society of Korea

2021 :Dopamine Modulates Spontaneous Activity in a subset of Type 1 Auditory Nerve Fibers. 44th Annual ARO Midwinter Virtual Meeting

2021 : Loss of inner hair cell ribbon synapse in aging mouse. 44th Annual ARO Midwinter Virtual Meeting

2022 : Auditory neuropathy in ATP1A3 mutant mouse is associated with decreased number of hair cell

ribbon synapses. 2022 Fall International convention of the Pharmaceutical Society of Korea

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윤구

직위(직급): 교수

연구분야: 의약화학

전화번호: 061-450-2682

이메일: gyoon@mnu.ac.kr

사무실: 약학관(C39) 4103호

교수소개

윤구

직위(직급): 교수

이메일: gyoon@mnu.ac.kr

연구분야: 의약화학

전화번호: 061-450-2682

사무실: 약학관(C39) 4103호

■ 학력

전남대학교 약학과 약학사

전남대학교 약학과 약학석사 (의약화학)

전남대학교 약학과 약학박사 (의약화학)

국립목포대학교 약학대학 약학과 교수 (의약화학)

■ 대표 연구실적

1. Yoon G, Shim JH, Kim HJ, Kim SN, Bae MS, Cho SS, Kim E. Structure–activity relationship of gallic acid from Paeonia lactiflora and its synthetic analogs against human breast cancer cells, Bull. Korean Chem. Soc. 2023 44(3), 222-229.

2. Kim, E., Kim, H. J., Cho, S. S., Shim, J. H., and Yoon, G. Isolation, semi-synthesis, and molecular modeling of deoxypodophyllotoxin analogs for an anti-oral cancer agent, Bull. Korean Chem. Soc. 41, 472-475 (2020).

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김현정

직위(직급): 교수

연구분야: 생약학

전화번호: 061-450-2686

이메일: hyunkim@mnu.ac.kr

사무실: 약학관(C39) 4210호

교수소개

김현정

직위(직급): 교수

이메일: hyunkim@mnu.ac.kr

연구분야: 생약학

전화번호: 061-450-2686

사무실: 약학관(C39) 4210호

■ 학력사항

전남대학교 : 약학과(약학사)
전남대학교 : 약학과(약학석사)
전남대학교 : 약학과(약학박사)

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조승식

직위(직급): 교수

연구분야: 약품미생물학

전화번호: 061-450-2687

이메일: sjason1@naver.com

사무실: 약학관(C39) 3107호

교수소개

조승식

직위(직급): 교수

이메일: sjason1@naver.com

연구분야: 약품미생물학

전화번호: 061-450-2687

사무실: 약학관(C39) 3107호

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심정현

직위(직급): 교수

연구분야: 약품생화학/세포분자생물학

전화번호: 061-450-2684

이메일: s1004jh@gmail.com (s1004jh@mnu.ac.kr)

사무실: 약학관(C39) 4205호

교수소개

심정현

직위(직급): 교수

이메일: s1004jh@gmail.com (s1004jh@mnu.ac.kr)

연구분야: 약품생화학/세포분자생물학

전화번호: 061-450-2684

사무실: 약학관(C39) 4205호

■ 학력사항

- 충남대학교 약학과 약학박사(생물약학/약품생화학·분자생물학)

■ 논문

- https://scholar.google.com/citations?user=g2rjc7EAAAAJ&hl=en

■ 학문적 경력 및 업적

○ 1999.11~2006.3: 한국생명공학연구 연구원

- 염증, 암, 대사성 질환의 조절물질을 신속하고 간편하게 탐색할 수 있는 일차적 탐색법을 확립 후 탐색 킷(kit)으로도 응용(항체, transgenic mouse 개발)

- 염증반응, 암예방, 항암 치료용 또는 치료보조용 조성물 및 식품 보조제 개발

- 바이러스성 발암 유전자 감염에 의해 발현 및 기능이 조절되어지는 싸이토카인 분석연구

○ 2006.3~2009.3: Hormel Institute, University of Minnesota 박사후 연구원

○ 2009.04~2011.02: 전북대학교 치의학전문대학원 기금교수

○ 2011.03~2013.02: 순천향 대학교 의과대학 조교수

○ 2013.03~현재: 목포대학교 약학대학 약학과 교수, 바이오의약보건생명융합학 협동과정 4단계 BK21 교수, RLRC 제 3세부 책임자, 약학과 학과장, 생명윤리 심의위원회 위원장, 연구실안전관리센터장, 동물실험실습관 관장, 천연약물연구소 소장, 바이오의약헬스케어연구소소장

- phytochemical의 항암 및 발암 과정 억제기전 분석

- 항염증 반응 효과 규명

- 다양한 암세포 또는 항암제 내성 암세포를 proteomics를 이용하여 타겟 발굴을 통한 암화기전 분석

- 폐암과 대장암에서 항암제 내성 세포모델 구축

- 천연물 유래 생리활성 물질 중 kinase inhibitor개발과 선도물질 도출(Licochalcone유도체, Podophyllotoxin 유도체)

■ 글로컬 인재양성

○ 2016.1.1.~현재: china-US (Henan) hormel cancer Institute 겸임교수

- 글로컬 인력양성 및 국제 공동 연구 수행(임상연구 및 PDX모델을 이용한 항암제 개발).

- 국제 공동 연구 및 학생교류

■ 전문성

○ 2016.1.1.~현재: International Journal of Oncology (IF 5.884) Editor

○ 2020.3.1.~현재: International Journal of Molecular Science(IF 6.208) Editor

○ 2020.11.1.~현재: 한국연구재단 생명과학단 기초생명 생화학 전문위원

○ 2021.1.1.~현재: Archives of Pharmacal Research(IF 6.01) Associate Editor

○ 2023.2.13.~현재: Frontiers in Public Health (IF 6.46) Associate Editor, Review Editor

■ 포상경력

○ 2016.2.24.: 2015 우수교육교수(목포대학교)

○ 2017.12.24.: 2016 학술우수 논문 분야 우수상, 2017 학술논문 분야 우수상(목포대학교)

○ 2018.2.19.: 2017 우수교육교수(목포대학교)

○ 2020.12.29.: 2020 학술논문 게재분야 우수상(목포대학교)

○ 2021.11.18.: 의약품 안전 및 제약산업 진흥 공로 표창장 (식품의약품안전처)

○ 2022.1.13. : 2021 학술논문게재 분야 우수상(목포대학교)

○ 2023.10.30.: 창조상(목포대학교)

○ 2024.4.15.: 2023 우수교육교수(목포대학교)

■ 학회 및 위원회 활동

○ 2012.1~현재 : 대한암예방학회 (종신회원, 정보간사, 학술간사, 출반간사, 출판 부위원장, 학술 부위원장, 윤리부위원장, 회원 위원장)

○ 2021.1~2014.12: 한국여성과학기술단체총연합회 (포상위원회 간사)

○ 2012.1~현재: 한국분자 세포생물학회(학술상위원회 위원, 윤리위원회 위원)

○ 2012.1.~2013.1: 한국생명과학회(편집위원회 심사위원)

○ 2012.1~현재: 대한약학회 (학술간사, 사업간사, 학술부위원장, 건물구입 추진위원회, 기획부위원장)

○ 2020.01~현재:여성생명과학기술포럼(운영위원, 기금위원)

○ 2020.01~현재: 한국응용약물학회(학술간사)

○ 2020.01~현재: 생화학분자생물학회(선거위원회 위원, 차기위원회 위원, 회원운영위원, 대의원, 윤리위원회 실무위원, 포상위원회 포상추천위원, 소식지편집위원, 윤리위원회 위원)

○ 2022.01~현재: 한국독성학회/한국환경성돌연변이 발암원학회 (기획위원회 위원)

○ 2022.01~현재: 한국프리라디칼 학회(출판위원)

○ 2022.11~현재: 전라남도경찰청(전남경찰청 집회시위자문위원회 위원)

○ 2022.11~현재: 충북바이오헬스산업혁신센터(3차년도 자체평가위원회 평가위원)

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박진우

직위(직급): 교수

연구분야: 물리약학/산업약학

전화번호: 061-450-2704

이메일: jwpark@mnu.ac.kr

사무실: 약학관(C39) 4206호

교수소개

박진우

직위(직급): 교수

이메일: jwpark@mnu.ac.kr

연구분야: 물리약학/산업약학

전화번호: 061-450-2704

사무실: 약학관(C39) 4206호

■ 학력사항

성균관대학교 : 화학공학과(공학사)

광주과학기술원 : 신소재공학과(공학석사)

서울대학교 : 제약학과(약학박사)

■ 논문실적

[1] Kim H, Park JW. Topical Delivery of Atraric acid derived from Stereocaulon japonicum with enhanced skin permeation and hair regrowth activity for androgenic alopecia. Pharmaceutics. 2023,15:340-361.

[2] Subedi L, Pandey P, Khadka B, Shim J-H, Cho S-S, Kweon S, Byun Y, Kim K-T, Park JW. Enhancement of the anticancer effect of atorvastatin-loaded nanoemulsions by improving oral absorption via multivalent intestinal transporter-targeting lipids. Drug Delivery. 2022, 29(1):3397-3413.

[3] Subedi L, Pandey P, Kang SH, Kim K-T, Cho S-S, Chang K-Y, Byun Y, Shim J-H, Park JW. Enhanced oral absorption of teriparatide with therapeutic potential for management of osteoporosis. Journal of Controlled Release. 2022,349:502-519.

[4] Kwak A-W, Lee J-Y, Lee S-O, Seo J-H, Park JW, Choi YH, Cho S-S, Yoon G, Lee M-H, Shim J-H. Echinatin induces reactive oxygen species-mediated apoptosis via JNK/p38 MAPK signaling pathway in colorectal cancer cells. Phytotherapy Research. 2022, doi: 10.1002/ptr.7634 (in press).

[5] Kwak A-W, Park JW, Lee S-O, Lee J-Y, Seo J-H, Yoon G, Lee M-H, Choi J-S, Shim J-H. Isolinderalactone sensitizes oxaliplatin-resistance colorectal cancer cells through JNK/p38 MAPK signaling pathways. Phytomedicine. 2022,105:154383-154396.

[6] Subedi L, Pandey P, Shim J-H, Kim K-T, Cho S-S, Koo K-T, Kim BJ, Park JW. Preparation of topical bimatoprost with enhanced skin infiltration and in vivo hair regrowth efficacy in androgenic alopecia. Drug Delivery. 2022,29(1):328-341.

[7] Maharjan R, Choi JU, Kweon S, Pangeni R, Lee NK, Park SJ, Chang K-Y, Park JW, Byun Y. A novel oral metronomic chemotherapy provokes tumor specific immunity resulting in colon cancer eradication in combination with anti-PD-1 therapy. Biomaterials. 2022;281:121334-12349.

[8] Maharjan R, Subedi L, Pangeni R, Jha SK, Kang SH, Chang K-Y, Byun Y, Jeong Uk Choi JU, Park JW. Metronomic delivery of orally available pemetrexed-incorporated colloidal dispersions for boosting tumor-specific immunity. Drug Delivery. 2021;28(1):2313-2328.

[9] Choi JU, Lee NK, Seo H, Chung SW, Al-Hilal TA, Park SJ, Kweon S, Min N, Kim SK, Ahn S, Kim UI, Park JW, et al. Anticoagulation therapy promotes the tumor immune-microenvironment and potentiates the efficacy of immunotherapy by alleviating hypoxia. Journal for ImmunoTherapy of Cancer. 2021;9(8):e002332.

[10] Choi JU, Kim J-Y, Chung SW, Lee NK, Park J, Kweon S, Cho YS, Kim HR, Lim SM, Park JW, Lee KC, Byun Y. Dual mechanistic TRAIL nanocarrier based on PEGylated heparin taurocholate and protamine which exerts both pro-apoptotic and anti-angiogenic effects. Journal of Controlled Release. 2021;336:181-191.

[11] Laxman S, Song S-Y, Jha SK, Lee S-H, Pangeni R, Koo K-T, Kim BJ, Cho S-S, Park JW. Preparation of Topical Itraconazole with Enhanced Skin/Nail Permeability and In Vivo Antifungal Efficacy against Superficial Mycosis. Pharmacutics. 2021;13(5):622-637.

[12] Kim SA, Nam G, Bae YR, Jha SK, Kim S, Choi Y, Lee Y, Kwon M, Jeong C, Byun Y, Park JW, Kim IS. Oral Cancer Immunotherapy through a Simvastatin-Loaded Colloidal Dispersion System for the Generation of Sustained Antitumor Immunity. Advanced Therapeutics. 2021;35(10):2100025-2100041.

[13] Pangeni R, Kang S, Jha SK, Subedi L, Park JW. Intestinal membrane transporter?mediated approaches to improve oral drug delivery. Journal of Pharmaceutical Investigation. 2021;51:137-158.

[14] Jha SK, Han HS, Subedi L, Pangeni R, Chung JY, Kweon S, Choi JU, Byun Y, Kim YH, Park JW. Enhanced oral bioavailability of an etoposide multiple nanoemulsion incorporating a deoxycholic acid derivative-lipid complex. Drug Delivery. 2020;27(1):1501-1503.

[15] Pangeni R, Subedi L, Jha SK, Kweon S, Kang SH, Chang KY, Choi JU, Byun Y, Park JW. Improvements in the oral absorption and anticancer efficacy of an oxaliplatin-loaded solid formulation: pharmacokinetic properties in rats and nonhuman primates and the effects of oral metronomic dosing on colorectal cancer. Int J Nanomedicine. 2020;15:7719-7743.

[16] Jha SK, Chung JY, Pangeni R, Choi HS, Subedi L, Kweon S, Choi JU, Byun Y, Kim YH, Park JW. Enhanced antitumor efficacy of bile acid-lipid complex-anchored docetaxel nanoemulsion via oral metronomic scheduling. J Control Release. 2020;328:368-394.

[17] Park DE, Adhikari D, Jha SK, Kim HJ, Park JW. The Antioxidant and Tyrosinase-inhibiting activities of 4-hydroxycinnamoyl-malate from a Citrus junos callus extract. J Nanosci Nanotechnol. 2020;20(9):5808-5812.

[18] Kang KW, Pangeni R, Park JW, Lee J, Yi E. Selective loss of calretinin-poor cochlear afferent nerve fibers in streptozotocin-induced hyperglycemic mice. J Nanosci Nanotechnol. 2020;20(9):5515-5519.

[19] Choi JU, Maharjan R, Pangeni R, Jha SK, Lee NK, Kweon S, Lee HK, Chang KY, Choi YK, Park JW, Byun Y. Modulating tumor immunity by metronomic dosing of oxaliplatin incorporated in multiple oral nanoemulsion. J Control Release. 2020;322:13-30.

[20] Seo SW, Park JW, Han DG, Kim JM, Kim S, Park T, Kang KH, Yang MH, Yoon IS. In vitro and in vivo assessment of metabolic drug interaction potential of dutasteride with ketoconazole. Pharmaceutics. 2019;11(12):673.

[21] Lee BC, Pangeni R, Na J, Koo KT, Park JW. Preparation and in vivo evaluation of a highly skin- and nail-permeable efinaconazole topical formulation for enhanced treatment of onychomycosis. Drug Delivery. 2019;26(1):1167-1177.

[22] Pangeni R, Jha SK, Maharjan R, Choi JU, Chang KY, Choi YK, Byun Y, Park JW. Intestinal transport mechanism and in vivo anticancer efficacy of a solid oral formulation incorporating an ion-pairing complex of pemetrexed with deoxycholic acid derivative. Int J Nanomedicine. 2019;14:6339-6356.

[23] Maharjan R, Pangeni R, Jha SK, Choi JU, Chang KY, Choi YK, Park JW, Byun Y. Anti-angiogenic effect of orally available pemetrexed for metronomic chemotherapy. Pharmaceutics. 2019;11:332-353.

[24] Jee JP, Pangeni R, Jha SK, Byun Y, Park JW. Preparation and in vivo evaluation of a topical hydrogel system incorporating highly skin-permeable growth factors, quercetin, and oxygen carriers for enhanced diabetic wound-healing therapy. Int J Nanomedicine. 2019;14:5449-5475.

[25] Pangeni R, Panthi VK, Yoon IS, Park JW. Preparation, characterization, and in vivo evaluation of an oral multiple nanoemulsive system for co-delivery of pemetrexed and quercetin. Pharmaceutics. 2018;10:158-180.

[26] Kim SB, Kim KS, Ryu HM, Hong SH, Kim BK, Kim DD, Park JW, Yoon IS. Modulation of rat hepatic cyp1a and 2c activity by honokiol and magnolol: differential effects on phenacetin and diclofenac pharmacokinetics in vivo. Molecules. 2018;23:1470-1482.

[27] Pangeni R, Choi JU, Panthi VK, Byun Y, Park JW. Enhanced oral absorption of pemetrexed by ion-pairing complex formation with deoxycholic acid derivative and multiple nanoemulsion formulations: preparation, characterization, and in vivo oral bioavailability and anticancer effect. Int J Nanomedicine. 2018;13:3329-3351.

[28] Park DE, Adhikari D, Pangeni R, Panthi VK, Kim HJ, Park JW. Preparation and characterization of callus extract from Pyrus pyrifolia and investigation of its effects on skin regeneration. Cosmetics. 2018;5(4):71.

[29] Mahmud F, Jeon OC, Alam F, Maharjan R, Choi JU, Park J, Lee S, Park JW, Lee DS, Byun Y. Oral pemetrexed facilitates low-dose metronomic therapy and enhances antitumor efficacy in lung cancer. J Control Release. 2018;284:160-170.

[30] Shankar S, Pangeni R, Park JW, Rhim JW. Preparation of sulfur nanoparticles and their antibacterial activity and cytotoxic effect. Mater Sci Eng C Mater Biol Appl. 2018;92:508-517.

[31] Choi SW, Oak MH, Yi E, Kim HJ, Park JW. Preparation and in vitro evaluation of elastic nanoliposomes for topical delivery of highly skin-permeable growth factors. J Nanosci Nanotechnol. 2018;18(2):887-892.

[32] Choi SW, Pangeni R, Jung DH, Kim SJ, Park JW. Construction and characterization of cell-penetrating peptide-fused fibroblast growth factor and vascular endothelial growth factor for an enhanced percutaneous delivery system. J Nanosci Nanotechnol. 2018;18(2):842-847.

[33] Adhikari D, Panthi VK, Pangeni R, Kim HJ, Park JW. Preparation, characterization, and biological activities of topical anti-aging ingredients in a Citrus junos callus extract. Molecules. 2017;22(12):2198.

[34] Kim HJ, Park JW. Anti-aging activities of Pyrus pyrifolia var culta plant callus extract. Trop. J. Pharm. Res. 2017;16 (7):1579-1588

[35] Pangeni R., Kang SW, Oak MH, Park EY, Park JW. Oral delivery of quercetin in oil-in-water nanoemulsion: In vitro characterization and in vivo anti-obesity efficacy in mice. J Funct Foods. 2017;38:571-581.

[36] Park JW, Hwang SR, Yoon IS. Advanced growth factor delivery systems in wound management and skin regeneration. Molecules. 2017;22(8):1259.

[37] Choi JU, Lee SW, Pangeni R, Byun Y, Yoon IS, Park JW. Preparation and in vivo evaluation of cationic elastic liposomes comprising highly skin-permeable growth factors combined with hyaluronic acid for enhanced diabetic wound-healing therapy. Acta Biomater. 2017;57:197-215.

[38] Choi SW, Pangeni R, Park JW. Nanoemulsion-based hydrogel for topical delivery of highly skin-permeable growth factor combinations: preparation and in vitro evaluation. J Nanosci Nanotechnol. 2017;17(4):2363-2369.

[39] Pangeni R, Choi SW, Jeon OC, Byun Y, Park JW. Multiple nanoemulsion system for an oral combinational delivery of oxaliplatin and 5-fluorouracil: preparation and in vivo evaluation. Int J Nanomedicine. 2016;11:6379-6399.

[40] Lee SY, Jung E, Park JH, Park JW, Shim CK, Kim DD, Yoon IS, Cho HJ. Transient aggregation of chitosan-modified poly(d,l-lactic-co-glycolic) acid nanoparticles in the blood stream and improved lung targeting efficiency. J Colloid Interface Sci. 2016;480:102-108.

[41] Hwang SR, Seo DH, Byun Y, Park JW. Preparation and in vivo evaluation of an orally available enteric-microencapsulated parathyroid hormone (1-34)-deoxycholic acid nanocomplex. Int J Nanomedicine. 2016;11:4231-4246.

[42] Bae J, Park JW. Topical delivery of leflunomide for rheumatoid arthritis treatment: evaluation of local tissue deposition of teriflunomide and its anti-inflammatory effects in an arthritis rat model. Drug Dev Ind Pharm. 2016;42(2):254-262.

[43] Jeon OC, Byun Y, Park JW. Preparation of oxaliplatin-deoxycholic acid derivative nanocomplexes and in vivo evaluation of their oral absorption and tumor growth suppression. J Nanosci Nanotechnol. 2016;16(2):2061-2064.

[44] Jeon OC, Seo DH, Kim HS, Byun Y, Park JW. Oral delivery of zoledronic acid by non-covalent conjugation with lysine-deoxycholic acid: In vitro characterization and in vivo anti-osteoporotic efficacy in ovariectomized rats. Eur J Pharm Sci. 2016;82:1-10.

[45] Hwang SR, Kim IJ, Park JW. Formulations of deoxycholic for therapy: a patent review (2011 - 2014). Expert Opin Ther Pat. 2015;25(12):1423-1440.

[46] Bae J, Park JW. Formulation and pharmacokinetic evaluation of controlled-release oxybutynin tablets in dogs. Trop. j. pharm. res. 2015;14(3):363-369.

[47] Park JW, Kim SJ, Kwag DS, Kim S, Park J, Youn YS, Bae YH, Lee ES. Multifunctional delivery systems for advanced oral uptake of peptide/protein drugs. Curr Pharm Des. 2015;21(22):3097-3110.

[48] Bae J, Park JW. Preparation of an injectable depot system for long-term delivery of alendronate and evaluation of its anti-osteoporotic effect in an ovariectomized rat model. Int J Pharm. 2015;480:37-47.

[49] Al-Hilal TA, Alam F, Park JW, Kim K, Kwon IC, Ryu GH, Byun Y. Prevention effect of orally active heparin conjugate on cancer-associated thrombosis. J Control Release. 2014;195:155-161.

[50] Won J, Park JW. Improvement of arbutin trans-epidermal delivery using radiofrequency microporation. Trop. j. pharm. res. 2014;13 (11):1775-1781.

[51] Bae IH, Park JW, Kim DY. Enhanced regenerative healing efficacy of a highly skin-permeable growth factor nanocomplex in a full-thickness excisional mouse wound model. Int J Nanomedicine. 2014;9:4551-4567.

[52] Shin KH, Yoon G, Yoon IS, Park JW. Preparation and evaluation of oral controlled-release cilostazol formulation: pharmacokinetics and antithrombotic efficacy in dogs and healthy male Korean participants. J Pharm Pharmacol. 2014;66:961-974.

[53] Park JW, Byun Y. Ionic complex of risedronate with positively charged deoxycholic acid derivative: evaluation of physicochemical properties and enhancement of intestinal absorption in rats. Arch Pharm Res. 2014;37(12):1560-1569.

[54] Al-Hilal TA, Park J, Alam F, Chung SW, Park JW, Kim K, Kwon IC, Kim IS, Kim SY, Byun Y. Oligomeric bile acid-mediated oral delivery of low molecular weight heparin. J Control Release. 2014;175:17-24.

[55] Cho HJ, Park JW, Yoon IS, Kim DD. Surface-modified solid lipid nanoparticles for oral delivery of docetaxel: enhanced intestinal absorption and lymphatic uptake. Int J Nanomedicine. 2014;9:495-504.

[56] Lee JH, Bae IH, Choi JK, Park JW. Evaluation of a highly skin permeable low-molecular-weight protamine conjugated epidermal growth factor for novel burn wound healing therapy. J Pharm Sci. 2013;102:4109-4120.

[57] Yoon G, Park JW, Yoon IS. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs): recent advances in drug delivery J Pharm Investig (2013) 43:353-362.

[58] Lee JO, Kim D, Kwag DS, Lee UY, Oh KT, Youn YS, Oh YT, Park JW, Lee ES. Gas-forming poly(ethylene glycol)-b-poly(L-lactic acid) micelles. Polym. Adv. Technol. 2013;24:551-556.

[59] Park JW, Hwang SR, Jeon OC, Moon HT, Byun Y. Enhanced oral absorption of ibandronate via complex formation with bile acid derivative. J Pharm Sci. 2013;102:341-346.

[60] Jeon OC, Hwang SR, Al-Hilal TA, Park JW, Moon HT, Lee S, Park JH, Byun Y. Oral delivery of ionic complex of ceftriaxone with bile acid derivative in non-human primates. Pharm Res. 2013;30(4):959-967.

[61] Choi JK, Jang JH, Jang WH, Kim J, Bae IH, Bae J, Park YH, Kim BJ, Lim KM, Park JW. The effect of epidermal growth factor (EGF) conjugated with low-molecular-weight protamine (LMWP) on wound healing of the skin. Biomaterials. 2012;33:8579-8590.

[62] Kim J, Jang JH, Lee JH, Choi JK, Park WR, Bae IH, Bae J, Park JW. Enhanced topical delivery of small hydrophilic or lipophilic active agents and epidermal growth factor by fractional radiofrequency microporation. Pharm Res. 2012;29:2017-2029.

[63] Lee DJ, Park GY, Oh KT, Oh NM, Kwag DS, Youn YS, Oh YT, Park JW, Lee ES. Multifunctional poly (lactide-co-glycolide) nanoparticles for luminescence/magnetic resonance imaging and photodynamic therapy. Int J Pharm. 2012;434(1-2):257-263.

[64] Park JW, Jeon OC, Kim SK, Al-Hilal TA, Lim KM, Moon HT, Kim CY, Byun Y. Pharmacokinetic evaluation of an oral tablet form of low-molecular-weight heparin and deoxycholic acid conjugate as a novel oral anticoagulant. Thromb Haemost. 2011;105:1060-1071.

[65] Lee D, Lim LA, Jang SB, Lee YJ, Chung JY, Choi JR, Kim K, Park JW, Yoon H, Lee J, Park MS, Park K. Pharmacokinetic comparison of sustained- and immediate-release oral formulations of cilostazol in healthy Korean subjects: a randomized, open-label, 3-part, sequential, 2-period, crossover, single-dose, food-effect, and multiple-dose study. Clin Ther. 2011;33(12):2038-2053.

[66] Kim CW, Yun JW, Bae IH, Park YH, Jeong YS, Park JW, Chung JH, Park YH, Lim KM. Evaluation of anti-platelet and anti-thrombotic effects of cilostazol with PFA-100® and Multiplate® whole blood aggregometer in vitro, ex vivo and FeCl3-induced thrombosis models in vivo. Thromb Res. 2011;127(6):565-570.

[67] Park JW, Jeon OC, Kim SK, Al-Hilal TA, Jin SJ, Moon HT, Yang VC, Kim SY, Byun Y. High antiangiogenic and low anticoagulant efficacy of orally active low molecular weight heparin derivatives. J Control Release. 2010;148:317-326.

[68] Eom JS, Koh KS, Al-Hilal TA, Park JW, Jeon OC, Moon HT, Byun Y. Antithrombotic efficacy of an oral low molecular weight heparin conjugated with deoxycholic asset on microsurgical anastomosis in rats. Thromb Res. 2010;126(3):e220-224.

[69] Park JW, Jeon OC, Kim SK, Al-Hilal TA, Moon HT, Kim CY, Byun Y. Anticoagulant efficacy of solid oral formulations containing a new heparin derivative. Mol Pharm. 2010;7(3):836-843.

[70] Park JW, Kim SK, Al-Hilal TA, Jeon OC, Moon HT, Byun Y. Strategies for Oral Delivery of Macromolecule Drugs. Biotechnol. Bioprocess Eng. 2010;15:66-75.

■ 지식재산권

2017 : 위장관 흡수증진제를 함유하는 부갑상선 호르몬의 경구 투여 제형 (국내 특허등록, 10-1796604)

2017 : 옥살리플라틴을 포함하는 경구용 약물전달 조성물 및 이의 제조방법 (국제 특허출원, PCT/KR2017/013958)

2017 : 세포투과형 성장인자들의 피부 생리활성 피부외용제 조성물 (국내 특허등록, 10-1813560)

2017 : 옥살리플라틴을 포함하는 경구용 약물전달 조성물 및 이의 제조방법 (국내 특허등록, 10-1895237)

2018 : 페메트렉시드를 포함하는 경구용 약학 조성물 및 이의 제조방법 (국제 특허출원, PCT/KR2018/011885)

2019 : 페메트렉시드를 포함하는 경구용 약학 조성물 및 이의 제조방법 (국내 특허등록, 10-2040034)

2021 : 지방분해 효과가 개선된 데옥시콜산 조성물 및 이의 제조 방법 (국내 특허출원, 10-2021-0019398)

2021 : 용해도와 투과성이 개선된 지용성 스타틴 조성물 및 이의 용도 (국내 특허출원, 10-2021-0034814)

2021 : 용액 형태의 국소 투여용 약학 조성물 및 이의 제조방법 (국내 특허출원, 10-2021-0049010)

2021 : LIPOPHILIC STATIN COMPOSITION WITH IMPROVED SOLUBILITY AND PERMEABILITY AND USES

THEREOF (국제 특허출원, PTC/KR2021/006868)

2021 : 비마토프로스트를 포함하는 국소 투여용 약학 조성물 (국내 특허출원, 10-2021-0173519)

2022 : 용액 형태의 국소 투여용 약학 조성물 및 이의 제조방법 (국내 특허등록, 10-2356831)

2022 : 테리파라타이드를 포함하는 골다공증 예방 또는 치료를 위한 경구용 약학적 조성물 및 이의 제조방

법 (국내 특허출원, 10-2022-0090893)

2022 : Pharmaceutical compositions for topical administration comprising bimatoprost (국제 특허출원, PCT/KR2022/019561)

2022 : 비마토프로스트를 포함하는 국소 투여용 약학 조성물 (국내 특허등록, 10-2482658)

■ 수상사항

2022 : 2022 한국약제학회 혁신기술상

■ 기술이전

2018 : 옥살리플라틴을 포함하는 경구용 약물전달 조성물 및 이의 제조방법, 페메트렉시드를 포함하는 경구용 약학 조성물 및 이의 제조방법

2019 : 위장관 흡수증진제를 함유하는 부갑상선 호르몬의 경구 투여 제형

2022 : 테리파라타이드를 포함하는 골다공증 예방 또는 치료를 위한 경구용 약학적 조성물 및 이의 제조방법

메일 보내기

백동재

직위(직급): 교수

연구분야: 약품합성학

전화번호: 061-450-2705

이메일: dbaek@mnu.ac.kr

사무실: 약학관(C39) 3207호

교수소개

백동재

직위(직급): 교수

이메일: dbaek@mnu.ac.kr

연구분야: 약품합성학

전화번호: 061-450-2705

사무실: 약학관(C39) 3207호

■ 학력사항
서울대학교 : 제약학과 약학박사 (의약화학전공)

■ 논문실적
1. SK1 inhibitor RB005 Induces Apoptosis in Colorectal Cancer Cells through SK1 Inhibition Dependent and Independent Pathway, Curr. Mol. Pharmacol. 2022, 15, 570

2. Synthesis of dansyl labeled sphingosine kinase 1 inhibitor, Chem. Phys. Lipids 2018, 215, 29

3. IgG Antibody Response Elicited by a Fully Synthetic Two-Component Carbohydrate-Based Cancer Vaccine Candidate with α-Galactosylceramide as Built-in Adjuvant, Org. Lett., 2017, 19(3), 456

4. Sphingosine 1-Phosphate Activation of EGFR as a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier, PLOS Pathog. 2016, e1005926

5. Structure and Dynamics of the Aliphatic Cholesterol Side Chain in Membranes as Studied by 2H NMR Spectroscopy and Molecular Dynamics Simulation, Phys. Chem. Chem. Phys. 2016, 18(5), 3730

메일 보내기

박은영

직위(직급): 교수

연구분야: 약물치료학

전화번호: 061-450-2706

이메일: parkey@mnu.ac.kr

사무실: 약학관(C39) 3206호

교수소개

박은영

직위(직급): 교수

이메일: parkey@mnu.ac.kr

연구분야: 약물치료학

전화번호: 061-450-2706

사무실: 약학관(C39) 3206호

■ 학력사항

서울대학교 : 약학(약학박사)

메일 보내기

김기택

직위(직급): 부교수

연구분야: 약제학 및 임상약동학

전화번호: 061-450-2688

이메일: ktkim0628@mnu.ac.kr

사무실: 약학관(C39) 4102호

교수소개

김기택

직위(직급): 부교수

이메일: ktkim0628@mnu.ac.kr

연구분야: 약제학 및 임상약동학

전화번호: 061-450-2688

사무실: 약학관(C39) 4102호

■ 학력사항

서울대학교 : 약제학(약학박사)

메일 보내기

김남아

직위(직급): 부교수

연구분야: 약품분석학 및 제제학

전화번호: 061-450-2685

이메일: namahk87@mnu.ac.kr

사무실: 약학관( C39) 4211호

교수소개

김남아

직위(직급): 부교수

이메일: namahk87@mnu.ac.kr

연구분야: 약품분석학 및 제제학

전화번호: 061-450-2685

사무실: 약학관( C39) 4211호

■ 학력사항

부산대학교 : (약학사)

부산대학교 : 물리약학(약학석사)

동국대학교 : 약제학(약학박사)

■ 논문실적

Hada, S., Na, K. J., Jeong, J., Choi, D. H., Kim, N. A., & Jeong, S. H. (2023). Evaluation of subvisible particles in human immunoglobulin and lipid nanoparticles repackaged from a multi-dose vial using plastic syringes. International Journal of Biological Macromolecules, 123439. [Equal corresponding author]

Kim, N.A., Noh, G.Y., Hada, S., Na, K.J., Yoon, H.J., Park, K.W., Park, Y.M. and Jeong, S.H., 2022. Enhanced protein aggregation suppressor activity of N-acetyl-l-arginine for agitation-induced aggregation with silicone oil and its impact on innate immune responses. International Journal of Biological Macromolecules. 216, 42-51.

Kim, M., Kim, J.H., Kim, S., Maharjan, R., Kim, N.A. and Jeong, S.H., 2022. New long-acting injectable microspheres prepared by IVL-DrugFluidic™ system: 1-month and 3-month in vivo drug delivery of leuprolide. International Journal of Pharmaceutics, p.121875. [Equal corresponding author]

Hada, S., Lee, J.C., Lee, E.C., Ji, S., Nam, J.S., Yun, B.J., Na, D.H., Kim, N.A. and Jeong, S.H., 2022. Dissociation mechanics and stability of type A botulinum neurotoxin complex by means of biophysical evaluation. Journal of Pharmaceutical Investigation, pp.1-11. [Equal corresponding author]

Maharjan, R., Jeong, J., Bhujel, R., Kim, M.-S., Han, H.-K., Kim, N. A., Jeong, S. H., Correlation of Solubility Thermodynamics of Glibenclamide with Recrystallization and In Vitro Release Profile, Molecules, 2022, 1392. [Equal corresponding author]

Park, S. -K., Noh, G. Y., Yu, H. W., Lee, E. C., Jeong, J., Park, Y. -M., Han, H. -K., Jeong, S. H., Kim, N. A., Lessons Learned in Protein Precipitation Using a Membrane Emulsification Technique to Produce Reversible and Uniform Microbeads, Pharmaceutics, 2021, 1738. [Equal corresponding author]

Kim, J. H., Ryu, C. H., Chon, C. H., Kim, S.., Lee, S., Maharjan, R., Kim, N. A., Jeong, S. H., Three months extended-release microspheres prepared by multi-microchannel microfluidics in beagle dog models, International Journal of Pharmaceutics 608, 2021, 121039. [Equal corresponding author]

Maharjan, R., Lee J. C., Kim, N. A., Jeong, S. H., Preparation of seeded granules to improve mechanical properties and various drug loading for pharmaceutical application, Powder Technology, 2021, 650-660. [Equal corresponding author]

Kim, N. A., Hada, S., Kim, D. J., Choi, D. H., Jeong, S. H., Off-label use of plastic syringes with silicone oil for intravenous infusion bags of antibodies, European Journal of Pharmaceutics and Biopharmaceutics, 2021, 205-215.

Kim, N. A., Yu, H. W., Noh, G.Y ., Park, S.-K., Kang, W., Jeong, S. H., Protein microbeadification to achieve highly concentrated protein formulation with reversible properties and in vivo pharmacokinetics after reconstitution, International Journal of Biological Macromolecules, 2021, 935-948.

Kim, N. A., Kar, S., Li, Z., Das, T. K., Carpenter, J. F., Mimicking Low pH Virus Inactivation Used in Antibody Manufacturing Processes: Effect of Processing Conditions and Biophysical Properties on Antibody Aggregation and Particle Formation. Journal of Pharmaceutical Sciences, 2021, 1-12.

Bhujel, R., Maharjan, R., Kim, N. A., Jeong, S. H., Practical quality attributes of polymeric microparticles with current understanding and future perspectives, Journal of Drug Delivery Science and Technology, 2021, 102608. [Equal corresponding author]

Kim, S. J., Lee, J. C., Ko, J. Y., Lee. S. H., Kim., N. A., Jeong, S. H., 3D-printed tablets using a single-step hot-melt pneumatic process for poorly soluble drugs. International Journal of Pharmaceutics. 2021, 595. [Equal corresponding author]

Maharjan, R., Tripathi, J., Kim, N. A., Park, K., Jeong, S. H., Solubility Determination of c-Met Inhibitor in Solvent Mixtures and Mathematical Modeling to Develop Nanosuspension Formulation. Molecules. 2021. 26, 390.

Kim, N. A., Hada, S., Jeong, S. H., N-Acetylated-L-arginine (NALA) is an enhanced protein aggregation suppressor under interfacial stresses and elevated temperature for protein liquid formulations. International Journal of Biological Macromolecules, 2021, 654-664.

Kim, N. A., Kim, D. J., Jeong, S. H., Do not flick or drop off-label use plastic syringes in handling therapeutic proteins before administration. International Journal of Pharmaceutics, 2020. 119704.

Kim, J., Park, K. E., Jeong, Y., Kim, Y., Park, H., Nam, J., Jung, K., Son, W. S., Jung, H. S., Lee, J., Jeong, S. H., Kim, N. A., Ha, J. D., Cho, S. Y., Choi, Y., Chung, S., Choi, J. Y., Hong, S., Shin, Y. K., Therapeutic Efficacy of ABN401, a Highly Potent and Selective MET Inhibitor, Based on Diagnostic Biomarker Test in MET-Addicted Cancer. Cancers, 2020. 1575.

Kim, N. A., Oh, H. K., Lee, J. C., Choi, Y. H., Jeong, S. H., Comparison of solubility enhancement by solid dispersion and micronized butein and its correlation with in vivo study. Journal of Pharmaceutical Investigation, 2020. 1-8.

Kim, N. A., Hong, S., Kim, K. H., Choi, D. H., Kim, J. S., Park, K. E., Choi, J. Y., Shin. Y. K., Jeong, S. H., New Preclinical Development of a c-Met Inhibitor and Its Combined Anti-Tumor Effect in c-Met-Amplified NSCLC. Pharmaceutics, 2020, 121.

Kim, N A., Heo, B., Jeong, H. J., Rapid methodology for basal system selection of therapeutic proteins during the early stage biopharmaceutical development. Journal of Pharmaceutical Investigation, 2019. 363-372.

Kim, N. A., Thapa, R., Jeong, S. H., Bae, H., Maeng, J., Lee, K., Park, K., Enhanced intranasal insulin delivery by formulations and tumor protein-derived protein transduction domain as an absorption enhancer. Journal of Controlled Release, 2019. 226-236.

Kim, K. H., Oh, H. K., Heo, B., Kim, N. A., Lim, D. G., & Jeong, S. H. (2018). Solubility evaluation and thermodynamic modeling of β-lapachone in water and ten organic solvents at different temperatures. Fluid Phase Equilibria, 472, 1-8.

Kim, N. A., Thapa, R., & Jeong, S. H. (2018). Preferential exclusion mechanism by carbohydrates on protein stabilization using thermodynamic evaluation. International journal of biological macromolecules, 109, 311-322.

Lim, D. G., Rajasekaran, N., Lee, D., Kim, N. A., Jung, H. S., Hong, S., ... & Jeong, S. H. (2017). Polyamidoamine-decorated nanodiamonds as a hybrid gene delivery vector and siRNA structural characterization at the charged interfaces. ACS applied materials & interfaces, 9(37), 31543-31556.

Kim, N. A., bok An, I., Lim, H. S., Yang, S. I., & Jeong, S. H. (2016). Biophysical evaluation of hybrid Fc fusion protein of hGH to achieve basal buffer system. International Journal of Pharmaceutics, 513(1-2), 421-430.

Kim, N. A., Hada, S., Thapa, R., & Jeong, S. H. (2016). Arginine as a protein stabilizer and destabilizer in liquid formulations. International Journal of Pharmaceutics, 513(1-2), 26-37.

Lim, J. Y., Kim, N. A., Lim, D. G., Kim, K. H., Choi, D. H., & Jeong, S. H. (2016). Process cycle development of freeze drying for therapeutic proteins with stability evaluation. Journal of Pharmaceutical Investigation, 46, 519-536.

Kim, N. A., Jin, J. H., Kim, K. H., Lim, D. G., Cheong, H., Kim, Y. H., ... & Jeong, S. H. (2016). Investigation of early and advanced stages in ovarian cancer using human plasma by differential scanning calorimetry and mass spectrometry. Archives of pharmacal research, 39, 668-676.

Lim, J. Y., Kim, N. A., Lim, D. G., Eun, C. Y., Choi, D., & Jeong, S. H. (2016). Biophysical stability of hyFc fusion protein with regards to buffers and various excipients. International journal of biological macromolecules, 86, 622-629.

Hada, S., Kim, N. A., Lim, D. G., Lim, J. Y., Kim, K. H., Adhikary, P., & Jeong, S. H. (2016). Evaluation of antioxidants in protein formulation against oxidative stress using various biophysical methods. International journal of biological macromolecules, 82, 192-200.

Kim, K. H., Lim, D. G., Lim, J. Y., Kim, N. A., Park, S. H., Cho, J. H., ... & Jeong, S. H. (2015). Chemical stability and in vitro and clinical efficacy of a novel hybrid retinoid derivative, bis-retinamido methylpentane. International Journal of Pharmaceutics, 495(1), 93-105.

Kim, N. A., Song, K., Lim, D. G., Hada, S., Shin, Y. K., Shin, S., & Jeong, S. H. (2015). Basal buffer systems for a newly glycosylated recombinant human interferon-β with biophysical stability and DoE approaches. European Journal of Pharmaceutical Sciences, 78, 177-189.

Lim, J. Y., Kim, N. A., Lim, D. G., Kim, K. H., Hada, S., & Jeong, S. H. (2015). Evaluation of etanercept degradation under oxidative stress and potential protective effects of various amino acids. International Journal of Pharmaceutics, 492(1-2), 127-136.

Um, S. H., Kim, J. S., Song, S., Kim, N. A., Jeong, S. H., & Ha, N. C. (2015). Crystal structure of DsbA from Corynebacterium diphtheriae and its functional implications for CueP in Gram-positive bacteria. Molecules and cells, 38(8), 715.

Lim, J. Y., Kim, N. A., Lim, D. G., Kim, K. H., & Jeong, S. H. (2015). Effects of thermal and mechanical stress on the physical stability of human growth hormone and epidermal growth factor. Archives of pharmacal research, 38, 1488-1498.

Kim, N. A., Lim, D. G., Lim, J. Y., Kim, K. H., & Jeong, S. H. (2015). Fundamental analysis of recombinant human epidermal growth factor in solution with biophysical methods. Drug Development and Industrial Pharmacy, 41(2), 300-306.

Kwon, M., Yeom, D., Kim, N. A., Choi, D. H., Park, J., Wang, H., ... & Jeong, S. H. (2015). Bioequivalence of tacrolimus formulations with different dynamic solubility and in-vitro dissolution profiles. Archives of pharmacal research, 38, 73-80.

Lim, D. G., Kim, N. A., Lim, J. Y., Kim, K. H., Hada, S., & Jeong, S. H. (2014). Evaluation of etanercept stability as exposed to various sugars with biophysical assessment. International Journal of Pharmaceutics, 476(1-2), 50-59.

Lim, D. G., Jeong, W. W., Kim, N. A., Lim, J. Y., Lee, S. H., Shim, W. S., ... & Jeong, S. H. (2014). Effect of the glyceryl monooleate-based lyotropic phases on skin permeation using in vitro diffusion and skin imaging. Asian journal of pharmaceutical sciences, 9(6), 324-329.

Kim, N. A., Lim, D. G., Lim, J. Y., Kim, K. H., Shim, W. S., Kang, N. G., & Jeong, S. H. (2014). Evaluation of protein formulation and its viscosity with DSC, DLS, and microviscometer. Journal of Pharmaceutical Investigation, 44, 309-316.

Song, K., Yoon, I. S., Kim, N. A., Kim, D. H., Lee, J., Lee, H. J., ... & Shin, Y. K. (2014). Glycoengineering of interferon-β 1a improves its biophysical and pharmacokinetic properties. PloS one, 9(5), e96967.

Kim, N. A., An, I. B., Lim, D. G., Lim, J. Y., Lee, S. Y., Shim, W. S., ... & Jeong, S. H. (2014). Effects of pH and buffer concentration on the thermal stability of etanercept using DSC and DLS. Biological and Pharmaceutical Bulletin, 37(5), 808-816.

Choi, D. H., Kim, N. A., Nam, T. S., Lee, S., & Jeong, S. H. (2014). Evaluation of taste-masking effects of pharmaceutical sweeteners with an electronic tongue system. Drug Development and Industrial Pharmacy, 40(3), 308-317.

Kim, N. A., Choi, D. H., Lim, J. Y., Kim, K. H., Lim, D. G., Lee, E., ... & Jeong, S. H. (2014). Investigation of polymeric excipients for dutasteride solid dispersion and its physicochemical characterization. Archives of pharmacal research, 37, 214-224.

Kim, N. A., Lim, D. G., Lim, J. Y., Kim, K. H., & Jeong, S. H. (2014). Comprehensive evaluation of etanercept stability in various concentrations with biophysical assessment. International journal of pharmaceutics, 460(1-2), 108-118.

Kim, N. A., An, I. B., Lee, S. Y., Park, E. S., & Jeong, S. H. (2012). Optimization of protein solution by a novel experimental design method using thermodynamic properties. Archives of pharmacal research, 35, 1609-1619.

Yun, B. Y., Jun, S. Y., Kim, N. A., Yoon, B. Y., Piao, S., Park, S. H., ... & Ha, N. C. (2011). Crystal structure and thermostability of a putative α-glucosidase from Thermotoga neapolitana. Biochemical and Biophysical Research Communications, 416(1-2), 92-98.

Shin, S., Choi, D. H., Truong, N. K. V., Kim, N. A., Chu, K. R., & Jeong, S. H. (2011). Time-oriented experimental design method to optimize hydrophilic matrix formulations with gelation kinetics and drug release profiles. International journal of pharmaceutics, 407(1-2), 53-62.

Choi, D. H., Kim, N. A., Chu, K. R., Jung, Y. J., Yoon, J. H., & Jeong, S. H. (2010). Material properties and compressibility using Heckel and Kawakita equation with commonly used pharmaceutical excipients. Journal of Pharmaceutical Investigation, 40(4), 237-244.

■ 특허실적

- Method for manufacture of protein microbead for improving stability of protein therapeutics, 1020210013460 (2021.01.29.), PCT 출원

- N-아세틸-L-아르기닌을 포함하는 단백질 응집 억제용 조성물 (10-2021-0161662), 공개

- Stabilized Formulations of Interferon beta Mutant 1020160129208 (2016.10.06.), PCT 출원

- 인터페론 베타 변이체의 안정화 제제, 1020160042320 (2016.04.06.), 한국 등록

- 트리아졸로피라진계 화합물, 결합제 및 붕해제를 포함하는 속방형 캡슐제 조성물, 1020170115782 (2017.09.11), 한국 등록

- Novel Polymorphic Forms of Triazolopyrazine Derivatives and Processes of Manufacturing Thereof, 1020170017440 (2017.02.08.), PCT 출원

메일 보내기

하동문

직위(직급): 조교수

연구분야: 사회약학

전화번호: 061-450-2708

이메일: dongmun@mnu.ac.kr

사무실: 약학관(C39) 3201호

교수소개

하동문

직위(직급): 조교수

이메일: dongmun@mnu.ac.kr

연구분야: 사회약학

전화번호: 061-450-2708

사무실: 약학관(C39) 3201호

■ 학력

Ph. D. in Social Pharmacy, School of Pharmacy, Sungkyunkwan University

MS. in Pharmaceutics, College of Pharmacy, Chonnam National University

BH. in Pharmacy, College of Pharmacy, Chosun University

■ 경력

Visiting Professor, Department of Health Sciences, Simon Fraser University

Research Professor, School of Pharmacy, Sungkyunkwan University

Executive Director, Korea Institute for Pharmaceutical Policy Affairs

■ 논문

Dongmun Ha, Jinchol Ryu, Yoonsoo Chun, Inmyung Song, and Ju-Young Shin,Differential characteristics and treatment of psoriasis patients by economic status in South Korea. Medicine: 13:99(46):e22410. doi: 10.1097/MD.0000000000022410 (2020) SCIE

Dongmun Ha, Seung Eun Lee, Inmyung Song, Sung Jun Lim, and Ju-Young Shin,Comparison of Signal Detection of Tumour Necrosis Factor-α Inhibitors using the Korea Adverse Events Reporting System Database, 2005–2016. Clin Rheumatol: 39(2):347-355. doi: 10.1007/s10067-019-04802-z (2020) SCIE

Park SH, Song I, Noh Y, Park H, Dongmun Ha, Shin JY, and Lee SW, Notable differences in drug lag between Korea and Japan of new drugs between 2009 and 2017. Ther Innov Regul Sci 54(2):418-423. doi: 10.1007/s43441-019-00071-9 (2020) SCIE

Yoon Na Hong and Dongmun Ha, A Comparative Analysis of Barriers for Korean Pharmaceutical Companies in Global Regulatory Affairs by Company Size. The Korean Journal of Health Service Management. 14(1): 55-65. Doi: 10.12811/kshsm.2020.14.1.055 (2020)

Onnuri Park, Kyoung won Jang, and Dongmun Ha, Comparative Study on the Regulations about In-Use Stability, and Analysis the In-Use Stability Application on Approved Syrups-Focused on the Guidelines in US, Europe and Korea. Journal of the Korea Academia-Industrial cooperation Society. 21(3): 137-146. https://doi.org/10.5762/KAIS.2020.21.3.137 (2020)

Sang Jae Lee and Dongmun Ha, Study of the Improvement of Domestic Regulations through Comparison ofDomestic and Foreign Blood Product (Blood Components) GMP Regulations. Yakhak Hoeji. 64(1): 65-72. DOI 10.17480/psk.2020.64.1.65 (2020)

Hyeok-Jin Kwon, Kyoung-Won Jang, and Dongmun Ha, Comparative Analysis of Prescription for Splitted Tablet using the HIRA-NPS (Health Insurance Review & Assessment Service-National Patient Sample). Korean College of Clinical Pharmacy. 29(4): 231-237. DOI : 10.24304/kjcp.2019.29.4.231 (2019)

Dongmun Ha, So-Ra Choi, Yongmin Kwon, Han-Heui Park, and Ju-Young Shin. Pattern of adverse events induced by aflibercept and ranibizumab: A nationwide spontaneous adverse event reporting database, 2007–2016. Medicine 98(33):e16785. doi: 10.1097/MD.0000000000016785 (2019) SCI

Dongmun Ha, Yeon-Ju Lee, Yoonsoo Chun, and Ju-Young Shin. Comparison of signal detection between statin and statin/ezetimibe fixed-dose combination using the Korea Adverse Events Reporting System Database, 2005–2016. Int J Clin Pharmacol Ther 57(10):489-499. doi: 10.5414/CP203374 (2019) SCI

Hae Yang Kim, Kyoung-Won Jang, and Dongmun Ha, A Comparative Study on the Regulation of Post-Approval Changes of domestic and foreign of Immediate Release Oral Dosage Forms: Focused on USA, Yakhak Hoeji. 63(3): 173-183. DOI : 10.17480/psk.2019.63.3.173 (2019)

Dongmun Ha, Inmyung Song, Sunyoung Park, and Eui-Kyung Lee. Factors Associated With the Management of Adverse Drug Reactions Among Community Pharmacists in South Korea J Patient Saf 15(2):143-149. doi: 10.1097/PTS.0000000000000211, (2019) SSCI

Sil Seong, Ju-Young Shin1, Daejin Kim, Inmyung Song, Sangouk Sun, Inok Kim, Sun-Kyeong Park and Dongmun Ha. The effect of tablet splitting on the mass loss, uniformity, and stability: by hand or splitter? Journal of Asian Association of Schools of Pharmacy 2019; 8: 7–14. (2019)

Seo-young Shin, Sangouk Sun and Dongmun Ha. The in-use stability study of multi-use ophthalmic solutions-Focused on Olopatadine, Fluorometholone, Dorzolamide, Timolol. Journal of the Korea Academia-Industrial cooperation Society. 2019; 20(2) 681–693. DOI: 10.5762/KAIS.2019.20.2.681 (2019)

Dongmun Ha, JeeYeon Lee, Dajeong Kim, In-Sun Oh, Eui-Kyung Lee, and Ju-Young Shin. Health Care Utilization and Medical Expenditure in Korean Psoriasis Patients using Health Insurance Database. Medicine. (24):e11070. doi:10.1097/MD.0000000000011070, (2018) SCI

Dongmun Ha, Inmyung Song, Eui-Kyung Lee, and Ju-Young Shin. Projection of future pharmacy service fees using the dispensing claims in hospital and clinic outpatient pharmacies: national health insurance database between 2006 and 2012. BMC Health Serv Res 3;18(1):327. doi: 10.1186/s12913-018-3067-0 (2018). SCIE

Kyoung-Won Jang, Gunhyuk Ko, and Dongmun Ha. Empirical Analysis of SFA (Sales Force Automation) System Utilization Level and Performance in Pharmaceutical Companies in Korea. Journal of the Korea Academia-Industrial cooperation Society. 2018; 19(11) 182–190. DOI: 10.5762/KAIS.2018.19.11.182 (2018)

Jiyoun Kim, Dongmun Ha, Inmyung Song, Haesun Park, Sang-Won Lee, Eui-Kyung Lee, and Ju-Young Shin. Estimation of cost savings between 2011 and 2014 attributed to infliximab biosimilar in the South Korean healthcare market: real-world evidence using a nationwide database. Int J Rheum Dis, 21(6):1227-1236. doi: 10.1111/1756-185X.13295 (2018). (Co-first Author) SCIE

Daejin Kim, Kihwan Oh, and Dongmun Ha. A Study on the Factors Influencing the Satisfaction of Certification and Support Policy of Innovative Pharmaceutical Companies : Focusing on the policy formation process variables. Journal of the Korea Academia-Industrial cooperation Society. 2018; 19(8) 360–369. DOI: 0.5762/KAIS.2018.19.8.360 (2018)

Jung Eun Hwang, Inmyung Song, Eui-Kyung Lee, Dongmun Ha, and Ju-Young Shin. Prevalence and predictors of tricyclic antidepressant use in primary-care and specialty clinics among the Korean elderly. Int J Clin Pharmacol Ther, 56(5):224-230. doi: 10.5414/CP203157 (2018). SCI

Namjoo Seo, Inmyung Song, Hyekyung Park, Dongmun Ha, and Ju-Young Shin. Trends in the prescribing of atypical antipsychotics among elderly patients with dementia in Korea. Int J Clin Pharmacol Ther, 55(7):581-587. doi: 10.5414/CP202951 (2017). SCI

Sun-Kyeong Park, Min-Young Lee, Eun-Jin Jang, Hye-Lin Kim, Dongmun Ha, and Eui-Kyung Lee. A comparison of discontinuation rates of tofacitinib and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis: A systematic review and Bayesian network meta-analysis. Clin Exp Rheumatol, 35(4):689-699 (2017). SCIE

Sun-Young Park, Eun-Ja Park, Hae Sun Suh, Dongmun Ha, and Eui-Kyung Lee. Development of a transformation model to derive general population-based utility: Mapping the pruritus-visual analog scale (VAS) to the EQ-5D utility. J Eval Clin Pract, 23(4):755-761. doi: 10.1111/jep.12711 (2017). SCIE

Dongmun Ha, Inmyung Song, Gyeongil Jang, Eui-Kyung Lee, and Ju-Young Shin. Use Pattern and Predictors of Use of Highly Caffeinated Energy Drinks among South Korean Adolescents: a study using the Health Belief Model. BMJ Open, 24;7(9):e017224. doi: 10.1136/bmjopen-2017-017224 (2017). SCIE

Dongmun Ha, Yong Choi, Dae Up Kim, Kyu Hyuck Chung, and Eui-Kyung Lee. A comparative analysis of the impact of a positive list system on new chemical entity drugs and incrementally modified drugs in south korea. Clinical Therapeutics 33(7):926-32. doi: 10.1016/j.clinthera.2011.05.089 (2011). SCIE

Jong Hyuk Park, Jong Hwan Kwak, Ja Heouk Khoo, Sung-Hoon Park, Dae Up Kim, Dongmun Ha, Sang Un Choi, Se Chan Kang, and Ok Pyo Zee. Cytotoxic effects of triterpenoid saponins from Androsace umbellata against multidrug resistance(MDR) and non-MDR cells. Arch Pharm Res, 33(8):1175-80. doi: 10.1007/s12272-010-0807-z (2010). SCIE

Dongmun Ha, Su Kyoung Lee, Dae Up Kim, Kyu Hyuck Chung and Eui Kyung Lee. A comparative Analysis of Perception of Health Professionals and Pharmaceutical Companies on the Positive List System. Yakhak Hoeji. 2010; 54(4) 309-315. (2010)

■ 저서

Jae-hyun Lee, Eui-Kyung Lee, Dongmun Ha, Kyung-il Jang, Miji Shin, Suna An, Ji-yeon Sung, Byung-hyuck Oh, Suna Choi,The text book for training of regulatory affairs professionals. The Ministry of Food and Drug Safety (2013)

Kyu-hyuck Chung, Eui-Kyung Lee, Ho-Young Mang, Mu-toung Ryu, Kyung-Ae Yun, Bo-yeon Kim, Kyung-ha Jang, Dongmun Ha, The guide bookfor Administrative Pharmacy practice of pharmacy school students. ISBN: 978-89-5702-283-293510, National Research Foundation of Korea (2011)

■ 수상

보건복지부장관상

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유지은

직위(직급): 조교수

연구분야: 병태생리학

전화번호: 061-450-2408

이메일: jieunyu@mnu.ac.kr

사무실: 약학관(C39) 3202호

교수소개

유지은

직위(직급): 조교수

이메일: jieunyu@mnu.ac.kr

연구분야: 병태생리학

전화번호: 061-450-2408

사무실: 약학관(C39) 3202호

■ 학력사항

- 충북대학교 약학과 약학박사

■ 논문실적

Yu JE, Yeo IJ, Han SB, Yun J, Kim BC, Yoon JY, Lim YS, Son DJ, Hong JT, “Significance of chitinase3-like protein 1 in the pathogenesis of inflammatory diseases and cancer”, Experimental & Molecular Medicine, 2024; 56(1):1-18

Kim BY, Yu JE, Yeo IJ, Son DJ, Lee HP, Roh YS, Lim KH, Yun J, Park HS, Han SB, Hong JT, “(E)-2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol alleviates inflammatory responses in LPS induced mice liver sepsis through inhibition of STAT3 phosphorylation”, International Immunopharmacology, 2023;125 (Co-first author)

Hong DE, Yu JE, Yoo SS, Yeo IJ, Son DJ, Yun J, Han SB, Hong JT, “CHI3L1 induces autophagy through the JNK pathway in lung cancer cells”, Scientific Reports, 2023;1(1) (Co-first author)

Yu JE, Yeo IJ, Yoo SS, Kim SH, Son DJ, Yun J, Han SB, Hong JE, “Induction of ER stress-mediated apoptosis through SOD1 upregulation by deficiency of CHI3L1 inhibits lung metastasis”, Theranostics, 2023;13(8):2693-2709

Hong DE, Yu JE, Lee JW, Song DJ, Lee HP, Kim Y, Chang JY, Lee DW, Lee WK, Yun J, Han SB, Hwang BY, Hong JT, “A Natural CHI3L1−Targeting Compound, Ebractenoid F, Inhibits Lung Cancer Cell Growth and Migration and Induces Apoptosis by Blocking CHI3L1/AKT Signals.”, Molecules, 2022;28(1):1-17

Yu JE, Kim Y, Hong DE, Lee DW, Chang JY, Yoo SS, Kim MJ, Son DJ, Yun J, Han SB, Hong JT, “Bee Venom Triggers Autophagy-Induced Apoptosis in Human Lung Cancer Cells via the mTOR Signaling Pathway.”, Journal of Oncology, 2022;2022:1-13

Yu JE, Yeo IJ, Lee DW, Chang JY, Son DJ, Yun J, Han SB, Hong JT, “Snake venom induces an autophagic cell death via activation of the JNK pathway in colorectal cancer cells.”, Journal of Cancer, 2022;13(12):3333-3341

Yu JE, Yeo IJ, Son DJ, Yun J, Han SB, Hong JT. “Anti-Chitinase-3-like 1 antibody suppressed tumor growth and metastasis through M2 polarization inhibition.”, Molecular oncology, 2022;16(11):2214-2234

Lee YS, Yu JE, Kim MJ, Ham HJ, Jeon SH, Yun J, Song SG, Lee CK, Han SB, Son DJ, Hong JT, “New therapeutic strategy for atopic dermatitis by targeting CHI3L1/ITGA5 axis.”, Clinical and Translational Medicine, 2022;12(2):1-6 (Co-first author)

Lee YS, Yu JE, Kim KC, Lee DH, Son DJ, Lee HP, Jung JK, Kim ND, Ham YW, Yun J, Han SB, Hong JT, “A small molecule targeting CHI3L1 inhibits lung metastasis by blocking IL-13Rα2-mediated JNK-AP-1 signals.”, Molecular oncology, 2021;16(2):508-526 (Co-first author)

Yu JE, Kim SO, Hwang JA, Hong JT, Hwang J, Soung NK, Cha-Molstad H, Kwon YT, Kim BY, Lee KH, “Phosphorylation of β-catenin Ser60 by polo-like kinase 1 drives the completion of cytokinesis.”, EMBO Reports, 2021;22(12):1-21

Hwang JA, Yu JE, Kim SO, Kim DH, Cho KS, Lee KH, “Wnt5a-induced docking of Plk1 on HEF1 promotes HEF1 translocation and tumorigenesis.”, Genes & Genomics, 2021;43(5):567-575 (Co-first author)

Cha-Molstad H, Yu JE, Feng Z, Lee SH, Kim JG, Yang P, Han B, Sung KW, Yoo YD, Hwang J, McGuire T, Shim SM, Song HD, Ganipisetti S, Wang N, Jang JM, Lee MJ, Kim SJ, Lee KH, Hong JT, Ciechanover A, Mook-Jung I, Kim KP, Xie XQ, Kwon YT, Kim BY., “p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis.”, Nature Communications, 2017;24:8(1):1-17 (Co-first author)

Cha-Molstad H, Yu JE, Lee SH, Kim JG, Sung KS, Hwang J, Yoo YD, Lee YJ, Kim ST, Lee DH, Ciechanover A, Kim BY, Kwon YT, “Modulation of SQTSM1/p62 activity by N-terminal arginylation of the endoplasmic reticulum chaperone HSPA5/GRP78/BiP.”, Autophagy, 2016;12(2):426-428 (Co-first author)

Cha-Molstad H, Sung KS, Hwang J, Kim KA, Yu JE, Yoo YD, Jang JM, Han DH, Molstad M, Kim JG, Lee YJ, Zakrzewska A, Kim SH, Kim ST, Kim SY, Lee HG, Soung NK, Ahn JS, Ciechanover A, Kim BY, Kwon YT, “N-terminal arginylation targets endoplasmic reticulum chaperone BiP to autophagy through p62 binding.”, Nature Cell Biology, 2015;17(9):917-929

메일 보내기

김기현

직위(직급): 조교수

연구분야: 산업약학

전화번호: 061-450-2386

이메일: kihyunkim@mnu.ac.kr

사무실: 약학관(C39) 2205호

교수소개

김기현

직위(직급): 조교수

이메일: kihyunkim@mnu.ac.kr

연구분야: 산업약학

전화번호: 061-450-2386

사무실: 약학관(C39) 2205호

■ 학력사항

부산대학교 : 약학부(약학사)

동국대학교 : 약학과(약학박사)

■ 경력사항

2017.12 ~ 2022.12 종근당 효종연구소 책임연구원

2023.01 ~ 2024.01 동국대학교 약학대학 연구교수

2024.01 ~ 현재 목포대학교 약학대학 조교수

■ 논문실적

Lee, J. C., Lee, E. C., Lee, Y. N., Hada, S., Lee, E. H., Kim, N. A., Kim. K. H.*, & Jeong, S. H*. (2024). Preparation of antibody-loaded protein microbeads for pulmonary delivery via Shirasu porous glass membrane emulsification and freeze drying. Journal of Drug Delivery Science and Technology, in press. [*Co-corresponding author]

Maharjan, R., Lee, J. C., Bøtker, J. P., Kim, K. H., Kim, N. A., Jeong, S. H., & Rantanen, J. (2024). Assessment of subvisible particles in biopharmaceuticals with image feature extraction and machine learning. Chemometrics and Intelligent Laboratory Systems, 245, 105061.

Maharjan, R., Lee, J. C., Lee, K., Han, H. K., Kim, K. H.*, & Jeong, S. H*. (2023). Recent trends and perspectives of artificial intelligence-based machine learning from discovery to manufacturing in biopharmaceutical industry. Journal of Pharmaceutical Investigation, 53(6), 803-826. [*Co-corresponding author]

Hada, S., Burlakoti, U., Kim, K. H., Han, J. S., Kim, M. J., Kim, N. A., & Jeong, S. H. (2023). A comprehensive evaluation of arginine and its derivatives as protein formulation stabilizers. International Journal of Pharmaceutics, 647, 123545.

Kim, K. H., Lee, J. E., Lee, J. C., Maharjan, R., Oh, H., Lee, K., Kim, N.A., & Jeong, S. H. (2023). Optimization of HPLC-CAD method for simultaneous analysis of different lipids in lipid nanoparticles with analytical QbD. Journal of Chromatography A, 1709, 464375.

Kim, K. H., Bhujel, R., Maharjan, R., Lee, J. C., Jung, H. S., Kim, H. J., Kim, N.A., & Jeong, S. H. (2023). Biophysical characterization of siRNA-loaded lipid nanoparticles with different PEG content in an aqueous system. European Journal of Pharmaceutics and Biopharmaceutics, 190, 150-160.

Hada, S., Ji, S., Lee, Y. N., Kim, K. H., Maharjan, R., Kim, N. A., Rantanen, J., & Jeong, S. H. (2023). Comparative study between a gravity-based and peristaltic pump for intravenous infusion with respect to generation of proteinaceous microparticles. International Journal of Pharmaceutics, 123091.

Maharjan, R., Hada, S., Lee, J. E., Han, H. K., Kim, K. H.*, Seo, H. J., Forged, C., & Jeong, S. H.* (2023). Comparative study of lipid nanoparticle-based mRNA vaccine bioprocess with machine learning and combinatorial artificial neural network-design of experiment approach. International Journal of Pharmaceutics, 640, 123012. [*Co-corresponding author]

Kim, K. H., Jun, M., & Lee, M. K. (2020). Bioavailability of the common cold medicines in jellies for oral administration. Pharmaceutics, 12(11), 1073.

Kim, N. A., Hong, S., Kim, K. H., Choi, D. H., Kim, J. S., Park, K. E., Choi, J. Y., Shin, Y. K., & Jeong, S. H. (2020). New preclinical development of a c-Met inhibitor and its combined anti-tumor effect in c-Met-amplified NSCLC. Pharmaceutics, 12(2), 121.

Kim, K. H., Oh, H. K., Heo, B., Kim, N. A., Lim, D. G., & Jeong, S. H. (2018). Solubility evaluation and thermodynamic modeling of β-lapachone in water and ten organic solvents at different temperatures. Fluid Phase Equilibria, 472, 1-8.

Lim, J. Y., Lim, D. G., Kim, K. H., Park, S. K., & Jeong, S. H. (2018). Effects of annealing on the physical properties of therapeutic proteins during freeze drying process. International Journal of Biological Macromolecules, 107, 730-740.

Kim, K. H., Le, T. H., Oh, H. K., Heo, B., Moon, J., Shin, S., & Jeong, S. H. (2017). Protective microencapsulation of β-lapachone using porous glass membrane technique based on experimental optimisation. Journal of Microencapsulation, 34(6), 545-559.

Lim, D. G., Prim, R. E., Kim, K. H., Kang, E., Park, K., & Jeong, S. H. (2016). Combinatorial nanodiamond in pharmaceutical and biomedical applications. International Journal of Pharmaceutics, 514(1), 41-51.

Lim, J. Y., Kim, N. A., Lim, D. G., Kim, K. H., Choi, D. H., & Jeong, S. H. (2016). Process cycle development of freeze drying for therapeutic proteins with stability evaluation. Journal of Pharmaceutical Investigation, 46, 519-536.

Lim, D. G., Kim, K. H.*, Kang, E., Lim, S. H., Ricci, J., Sung, S. K., Kwon, M. T., & Jeong, S. H. (2016). Comprehensive evaluation of carboxylated nanodiamond as a topical drug delivery system. International Journal of Nanomedicine, 2381-2395. [*Co-first author]

Lee, S. H., Shim, W. S., Ryu, J. S., Park, S. G., Lee, C. K., Kim, K. H., Jeong, S. H. & Kang, N. K. (2016). Physicochemical Properties of the Poorly Soluble Isoflavone Class-loaded Hydrocolloid Patch. Polymer(Korea), 40(3), 380-384.

Kim, K. H., Park, S. H., Adhikary, P., Cho, J. H., Kang, N. G., & Jeong, S. H. (2016). Stability of β-lapachone upon exposure to various stress conditions: resultant efficacy and cytotoxicity. Chemical and Pharmaceutical Bulletin, 64(5), 381-389.

Hada, S., Kim, N. A., Lim, D. G., Lim, J. Y., Kim, K. H., Adhikary, P., & Jeong, S. H. (2016). Evaluation of antioxidants in protein formulation against oxidative stress using various biophysical methods. International Journal of Biological Macromolecules, 82, 192-200.

Kim, K. H., Lim, D. G., Lim, J. Y., Kim, N. A., Park, S. H., Cho, J. H., Shin, B. S., & Jeong, S. H. (2015). Chemical stability and in vitro and clinical efficacy of a novel hybrid retinoid derivative, bis-retinamido methylpentane. International Journal of Pharmaceutics, 495(1), 93-105.

Lim, J. Y., Kim, N. A., Lim, D. G., Kim, K. H., Hada, S., & Jeong, S. H. (2015). Evaluation of etanercept degradation under oxidative stress and potential protective effects of various amino acids. International Journal of Pharmaceutics, 492(1-2), 127-136.

Lim, J. Y., Kim, N. A., Lim, D. G., Kim, K. H., & Jeong, S. H. (2015). Effects of thermal and mechanical stress on the physical stability of human growth hormone and epidermal growth factor. Archives of Pharmacal Research, 38, 1488-1498.

Kim, N. A., Lim, D. G., Lim, J. Y., Kim, K. H., & Jeong, S. H. (2015). Fundamental analysis of recombinant human epidermal growth factor in solution with biophysical methods. Drug Development and Industrial Pharmacy, 41(2), 300-306.

Lim, D. G., Kim, N. A., Lim, J. Y., Kim, K. H., Hada, S., & Jeong, S. H. (2014). Evaluation of etanercept stability as exposed to various sugars with biophysical assessment. International Journal of Pharmaceutics, 476(1-2), 50-59.

Kim, K. H., Cho, S. A., Lim, J. Y., Lim, D. G., Moon, C., & Jeong, S. H. (2014). Preparation of microcapsules with the evaluation of physicochemical properties and molecular interaction. Archives of Pharmacal Research, 37, 1570-1577.

Kim, N. A., Lim, D. G., Lim, J. Y., Kim, K. H., Shim, W. S., Kang, N. G., & Jeong, S. H. (2014). Evaluation of protein formulation and its viscosity with DSC, DLS, and microviscometer. Journal of Pharmaceutical Investigation, 44, 309-316.

Kim, N. A., Choi, D. H., Lim, J. Y., Kim, K. H., Lim, D. G., Lee, E., Park, E. S., & Jeong, S. H. (2014). Investigation of polymeric excipients for dutasteride solid dispersion and its physicochemical characterization. Archives of pharmacal research, 37, 214-224.

Kim, N. A., Lim, D. G., Lim, J. Y., Kim, K. H., & Jeong, S. H. (2014). Comprehensive evaluation of etanercept stability in various concentrations with biophysical assessment. International Journal of Pharmaceutics, 460(1-2), 108-118.

Choi, D. H., Kim, K. H., Park, J. S., Jeong, S. H., & Park, K. (2013). Evaluation of drug delivery profiles in geometric three-layered tablets with various mechanical properties, in vitro–in vivo drug release, and Raman imaging. Journal of Controlled Release, 172(3), 763-772.

■ 특허실적

N-아세틸-아미노산을 포함하는 동결 건조 조성물, 10-2024-0019148, 2024.02.07 (국내 출원)

엠파글리플로진 공결정을 함유하는 약제학적 조성물, 10-2024-0010065, 2024.01.08 (국내 출원)

도네페질 및 메만틴을 포함하는 복합 제제, KR 10-2604761, 2023.11.16 (국내 등록)

사쿠비트릴ㆍ발사르탄 칼륨염을 포함하는 약제학적 조성물, 10-2022-0119359, 2022.09.21 (국내 출원)

Novel polymorphs of a triazolopyrazine derivative and process for their preparation, CN 110049988, 2022.07.05 (국제 등록)

Pharmaceutical composition comprising empagliflozin co-crystal, PCT/KR2021/018414, 2021.12.07 (국제 출원)

Novel polymorph of triazolo pyrazine derivative and method for preparing same, EP 3459954, 2021.05.26 (국제 등록)

A novel polymorph of triazolopyrazine derivative and its production method, JP 6833300, 2021.02.24 (국제 등록)

엠파글리플로진 공결정을 함유하는 약제학적 조성물, 10-2020-0170136, 2020.12.08 (국내 출원)

Complex formulation comprising donepezil and memantine, PCT/KR2020/010057, 2020.07.30 (국제 출원)

Polymorphic forms of triazolopyrazine derivatives and method of preparing the same, US 10538529, 2020.01.21 (국제 등록)

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강소영

직위(직급): 조교수

연구분야: 임상약학

전화번호: 061-450-2368

이메일: sykang@mnu.ac.kr

사무실: 약학관(C39) 2204호

교수소개

강소영

직위(직급): 조교수

이메일: sykang@mnu.ac.kr

연구분야: 임상약학

전화번호: 061-450-2368

사무실: 약학관(C39) 2204호

* 학력

- 서울대학교 (농학사)

- 서울대학교 분자생물학(농학석사)

- 연세대학교 (약학사)

- 연세대학교 임상약학(약학박사)

* 경력

- CJ제일제당 바이오연구소

- 세브란스병원

- 한국의약품안전관리원

* 논문

Kang, S., Yeon, B., Kim, M. S., Yoo, M., Kim, B., & Yu, Y. M. (2023). Aneurysm and Artery Dissection After Oral VEGFR-TKI Use in Adults With Cancer. JAMA Network Open, 6(11), e2345977-e2345977.

Kang, S., Yang, S., Hahn, J., Jang, J. Y., Min, K. L., Wi, J., & Chang, M. J. (2022). Dose Optimization of Meropenem in Patients on Veno-Arterial Extracorporeal Membrane Oxygenation in Critically Ill Cardiac Patients: Pharmacokinetic/Pharmacodynamic Modeling. Journal of Clinical Medicine, 11(22), 6621.

Park, G., Choi, B., Kang, S., Kim, B., & Chang, M. J. (2022). Sodium–Glucose Cotransporter-2 Inhibitors Could Help Delay Renal Impairment in Patients with Type 2 Diabetes: A Real-World Clinical Setting. Journal of Clinical Medicine, 11(18), 5259.

Hahn, J., Min, K. L., Kang, S., Yang, S., Park, M. S., Wi, J., & Chang, M. J. (2021). Population pharmacokinetics and dosing optimization of piperacillin-tazobactam in critically ill patients on extracorporeal membrane oxygenation and the influence of concomitant renal replacement therapy. Microbiology spectrum, 9(3), e00633-21.

Lee, S. M., Yang, S., Kang, S., & Chang, M. J. (2021). Population pharmacokinetics and dose optimization of vancomycin in neonates. Scientific reports, 11(1), 6168.

Kang, S., Jang, J. Y., Hahn, J., Kim, D., Lee, J. Y., Min, K. L., ... & Chang, M. J. (2020). Dose optimization of cefpirome based on population pharmacokinetics and target attainment during extracorporeal membrane oxygenation. Antimicrobial agents and chemotherapy, 64(5), 10-1128.

Kang, S., Park, J., Yu, Y. M., Park, M. S., Han, E., & Chang, M. J. (2019). Comparison of acute kidney injury and clinical prognosis of vancomycin monotherapy and combination therapy with beta-lactams in the intensive care unit. PLoS One, 14(6), e0217908.

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